abstract：:The Solute Carrier Family 24 (SLC24) belongs to the CaCA super family of Ca(2+)/cation antiporters and codes for five different K(+)- dependent Na(+)- Ca(2+) exchangers (NCKX1-5). NCKX proteins play a critical role in Ca(2+) homeostasis in a wide variety of biological processes such as vision, olfaction, enamel format...

journal_title：Cell calcium

authors： Jalloul AH,Szerencsei RT,Schnetkamp PP

更新日期：2016-01-01 00:00:00

abstract：:Localized subcellular changes in Ca(2+) serve as important cellular signaling elements, regulating processes as diverse as neuronal excitability and gene expression. Studies of cellular Ca(2+) signaling have been greatly facilitated by the availability of fluorescent Ca(2+) indicators. The respective merits of differe...

journal_title：Cell calcium

authors： Lock JT,Parker I,Smith IF

更新日期：2015-12-01 00:00:00

abstract：:The type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) mediates increases in the intracellular concentration of Ca(2+) ([Ca(2+)]i) during fertilization in mammalian eggs. The activity of IP3R1 is enhanced during oocyte maturation, and phosphorylations by M-phase kinases are thought to positively regulate the activit...

journal_title：Cell calcium

authors： Zhang N,Yoon SY,Parys JB,Fissore RA

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Previous studies suggest that CaMKII activity is required for frequency-dependent acceleration of relaxation (FDAR) in ventricular myocytes. We propose that the underlying mechanism involves CaMKII-dependent regulation of myofilament Ca(2+) sensitivity. METHODS AND RESULTS:Cardiac function was measured in m...

journal_title：Cell calcium

authors： Guilbert A,Lim HJ,Cheng J,Wang Y

更新日期：2015-11-01 00:00:00

abstract：:Store-operated calcium entry (SOCE) is activated within the endoplasmic reticulum (ER)-plasma membrane (PM) junctions in the plasma membrane and involves assembly of the channels, Orai1 and TRPC1, with the regulatory protein, STIM1, in response to depletion of Ca(2+) in the ER. The dynamic assembly of the channel comp...

journal_title：Cell calcium

authors： Ong HL,Ambudkar IS

更新日期：2015-10-01 00:00:00

abstract：:Acidic organelles such as lysosomes serve as non-canonical Ca(2+) stores. The Ca(2+) mobilising messenger NAADP is thought to trigger local Ca(2+) release from such stores. These events are then amplified by Ca(2+) channels on canonical ER Ca(2+) stores to generate physiologically relevant global Ca(2+) signals. Coupl...

journal_title：Cell calcium

authors： Penny CJ,Kilpatrick BS,Eden ER,Patel S

更新日期：2015-10-01 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a progressive muscle disease with severe cardiac complications. It is believed that cellular oxidative stress and augmented Ca(2+) signaling drives the development of cardiac pathology. Some mitochondrial and metabolic dysfunctions have also been reported. Here we investigate cellu...

journal_title：Cell calcium

authors： Kyrychenko V,Poláková E,Janíček R,Shirokova N

更新日期：2015-08-01 00:00:00

abstract：:The endoplasmic reticulum (ER) acts as a dynamic calcium store and is involved in the generation of specific patterns of calcium signals in neurons. Calcium is mobilized from the ER store by multiple signaling cascades, and neuronal activity is known to regulate ER calcium levels. We asked how neurons regulate ER calc...

journal_title：Cell calcium

authors： Samtleben S,Wachter B,Blum R

更新日期：2015-08-01 00:00:00

abstract：:Atypical absence epilepsy (AAE) is an intractable disorder characterized by slow spike-and-wave discharges in electroencephalograms (EEGs) and accompanied by severe cognitive dysfunction and neurodevelopmental or neurological deficits in humans. Administration of the cholesterol biosynthesis inhibitor AY-9944 (AY) dur...

journal_title：Cell calcium

authors： Jung S,Jeong Y,Jeon D

更新日期：2015-05-01 00:00:00

abstract：:Reference treatment of advanced prostate cancer (PCa) relies on pharmacological or surgical androgen deprivation therapy. However, it is only temporarily efficient as tumor cells inevitably adapt to the low testosterone environment and become hormone-refractory (HRPCa). We observed that androgen removal in HRPCa-deriv...

journal_title：Cell calcium

authors： Boutin B,Tajeddine N,Monaco G,Molgo J,Vertommen D,Rider M,Parys JB,Bultynck G,Gailly P

更新日期：2015-04-01 00:00:00

abstract：:Animals have evolved sophisticated physiological systems for sensing ambient temperature since changes in environmental temperatures affect various biological processes. Thermosensitive transient receptor potential (thermoTRP) channels serve as thermal sensors in diverse animal species. They are multimodal receptors t...

journal_title：Cell calcium

authors： Saito S,Tominaga M

更新日期：2015-03-01 00:00:00

abstract：:Cytosolic Ca(2+) signals are fundamental for the early and late steps of myoblast differentiation and are, as in many cells, generated by Ca(2+) release from internal stores as well as by plasma membrane Ca(2+) entry. Our recent studies identified the store-operated Ca(2+) channels, Orai1 and TRPC1&C4, as crucial for ...

journal_title：Cell calcium

authors： Antigny F,Konig S,Bernheim L,Frieden M

更新日期：2014-12-01 00:00:00

abstract：:Turnover of the cartilage extracellular matrix depends exclusively on chondrocytes and varies in response to load and osmolarity fluctuations. Obesity can affect chondrocyte physiology; adipokines, insulin and proinflammatory cytokines levels are all altered in the obese and are related to matrix turnover impairments ...

journal_title：Cell calcium

authors： Sánchez JC,López-Zapata DF,Wilkins RJ

更新日期：2014-12-01 00:00:00

abstract：:Calcium ion is involved in diverse physiological and developmental pathways. One of the important roles of calcium is a signaling messenger, which regulates signal transduction in plants. CBL (calcineurin B-like protein) is one of the calcium sensors that specifically interact with a family of serine-threonine protein...

journal_title：Cell calcium

authors： Kanwar P,Sanyal SK,Tokas I,Yadav AK,Pandey A,Kapoor S,Pandey GK

更新日期：2014-08-01 00:00:00

abstract：:In previous works, we have shown that L-type voltage-operated calcium channels, N-methyl-d-aspartate receptors (NMDAr), neuronal nitric oxide synthase (nNOS) and cytochrome b5 reductase (Cb5R) co-localize within the same lipid rafts-associated nanodomains in mature cerebellar granule neurons (CGN). In this work, we sh...

journal_title：Cell calcium

authors： Marques-da-Silva D,Gutierrez-Merino C

更新日期：2014-08-01 00:00:00

abstract：:The mitochondrial permeability transition pore (mPTP) has long been known to have a role in mitochondrial calcium (Ca(2+)) homeostasis under pathological conditions as a mediator of the mitochondrial permeability transition and the activation of the consequent cell death mechanism. However, its role in the context of ...

journal_title：Cell calcium

authors： De Marchi E,Bonora M,Giorgi C,Pinton P

更新日期：2014-07-01 00:00:00

abstract：:The Ca(2+) and cAMP/PKA pathways are the primary signaling systems in secretory epithelia that control virtually all secretory gland functions. Interaction and crosstalk in Ca(2+) and cAMP signaling occur at multiple levels to control and tune the activity of each other. Physiologically, Ca(2+) and cAMP signaling oper...

journal_title：Cell calcium

authors： Ahuja M,Jha A,Maléth J,Park S,Muallem S

更新日期：2014-06-01 00:00:00

abstract：:Parvalbumin (PA) is a Ca(2+)-binding protein of vertebrates massively expressed in tissues with high oxygen uptake and respectively elevated level of reactive oxygen species (ROS). To characterize antioxidant properties of PA, antioxidant capacity (AOC) of intact rat α-PA has been explored. ORAC, TEAC and hydrogen per...

journal_title：Cell calcium

authors： Permyakov SE,Kazakov AS,Avkhacheva NV,Permyakov EA

更新日期：2014-05-01 00:00:00

abstract：:Cardiogenesis depends on a tightly regulated balance between proliferation and differentiation of cardiac progenitor cells (CPCs) and their cardiomyocyte descendants. While exposure of early mouse embryos to Ca(2+) channel antagonists has been associated with abnormal cardiac morphogenesis, less is known about the con...

journal_title：Cell calcium

authors： Hotchkiss A,Feridooni T,Zhang F,Pasumarthi KB

更新日期：2014-05-01 00:00:00

abstract：:Infrared neural stimulation (INS) is a promising neurostimulation technique that can activate neural tissue with high spatial precision and without the need for exogenous agents. However, little is understood about how infrared light interacts with neural tissue on a cellular level, particularly within the living brai...

journal_title：Cell calcium

authors： Cayce JM,Bouchard MB,Chernov MM,Chen BR,Grosberg LE,Jansen ED,Hillman EM,Mahadevan-Jansen A

更新日期：2014-04-01 00:00:00

abstract：:We have recently shown that freshly isolated astrocytes from the mouse brain express mRNA for the L-channel gene Cav1.3 to at least the same degree (per mg mRNA) as corresponding neurons. The amount of extracellular Ca(2+) actually entering cultured astrocytes by its opening is modest, but due to secondary Ca(2+)-medi...

journal_title：Cell calcium

authors： Du T,Liang C,Li B,Hertz L,Peng L

更新日期：2014-03-01 00:00:00

abstract：:Endothelin-1 (ET-1), a potent vasoactive peptide with a pathogenic role in vascular diseases, has been shown to induce the activation of ERK1/2, PKB and the expression of a transcriptional regulator, the early growth response 1 (Egr-1), key mediators of hypertrophic and proliferative responses in vascular smooth muscl...

journal_title：Cell calcium

authors： Bouallegue A,Simo Cheyou ER,Anand-Srivastava MB,Srivastava AK

更新日期：2013-12-01 00:00:00

abstract：:The importance of Ca(2+) signaling in astrocytes is undisputed but a potential role of Ca(2+) influx via L-channels in the brain in vivo is disputed, although expression of these channels in cultured astrocytes is recognized. This study shows that an increase in free cytosolic Ca(2+) concentration ([Ca(2+)]i) in astro...

journal_title：Cell calcium

authors： Yan E,Li B,Gu L,Hertz L,Peng L

更新日期：2013-11-01 00:00:00

abstract：:Nanosecond-duration electric stimuli are distinguished by the ability to permeabilize intracellular membranes and recruit Ca2+ from intracellular stores. We quantified this effect in non-excitable cells (CHO) using ratiometric Ca2+ imaging with Fura-2. In a Ca(2+)-free medium, 10-, 60-, and 300-ns stimuli evoked Ca2+ ...

journal_title：Cell calcium

authors： Semenov I,Xiao S,Pakhomova ON,Pakhomov AG

更新日期：2013-09-01 00:00:00

abstract：:It is well established that intracellular calcium ([Ca2+]i) controls the inotropic state of the myocardium, and evidence mounts that a "Ca2+ clock" controls the chronotropic state of the heart. Recent findings describe a calcium-activated nonselective cation channel (NSCCa) in various cardiac preparations sharing hall...

journal_title：Cell calcium

authors： Burt R,Graves BM,Gao M,Li C,Williams DL,Fregoso SP,Hoover DB,Li Y,Wright GL,Wondergem R

更新日期：2013-09-01 00:00:00

abstract：:Antigen-mediated mast cell (MC) degranulation is the critical early event in the induction of allergic reactions. Transient receptor potential channels (TRPC), particularly TRPC1, are thought to contribute to such MC activation. To explore the contribution of TRPC1 in MC-driven allergic reactions, we examined antigen-...

journal_title：Cell calcium

authors： Medic N,Desai A,Olivera A,Abramowitz J,Birnbaumer L,Beaven MA,Gilfillan AM,Metcalfe DD

更新日期：2013-05-01 00:00:00

abstract：:Peripheral astrocytic processes (PAPs) are highly motile structures that are strategically positioned in close proximity to synapses. Long-lasting PAP retraction in hypothalamus is known to alter synaptic transmission. The PAP motility is likely to be actin-based because they are known to contain actin-related protein...

journal_title：Cell calcium

authors： Molotkov D,Zobova S,Arcas JM,Khiroug L

更新日期：2013-05-01 00:00:00

abstract：:Calcium entry from the extracellular space into cells is an important signaling mechanism in both physiological and pathophysiological functions. In non-excitable cells, store-operated calcium (SOC) entry represents a principal mode of calcium entry. Activation of SOC entry in pulmonary artery endothelial cells leads ...

journal_title：Cell calcium

authors： Kadeba PI,Vasauskas AA,Chen H,Wu S,Scammell JG,Cioffi DL

更新日期：2013-04-01 00:00:00

abstract：:Several recent reports have demonstrated how engineered proteins can control cell motility, an important functional module for ultimately programming cells as therapeutics. We have reported two engineered proteins that regulate the blebbing cell morphology using chimeras of RhoA, a protein that regulates cytoskeletal ...

journal_title：Cell calcium

authors： Mills E,Truong K

更新日期：2013-03-01 00:00:00

abstract：:Store operated Ca(2+) entry (SOCE) replenishes intracellular Ca(2+) stores and activates a number of intracellular signalling pathways. Whilst several molecular components forming store operated Ca(2+) channels (SOCC) have been identified, their modulation in neurons remains poorly understood. Here, we extend on our p...

journal_title：Cell calcium

authors： Koss DJ,Riedel G,Bence K,Platt B

更新日期：2013-02-01 00:00:00

abstract：:In many animals, a rise in intracellular calcium levels is the trigger for egg activation, the process by which an arrested mature oocyte transitions to prepare for embryogenesis. In nearly all animals studied to date, this calcium rise, and thus egg activation, is triggered by the fertilizing sperm. However in the in...

journal_title：Cell calcium

authors： Sartain CV,Wolfner MF

更新日期：2013-01-01 00:00:00

abstract：:In addition to its role in artery contraction, Rho kinase (ROCK) is reported to be involved in the Ca(2+) response to vasoconstrictor agonist in rat aorta. However the signaling pathway mediated by ROCK had not been investigated so far and it was not known whether ROCK also contributed to Ca(2+) signaling in cultured ...

journal_title：Cell calcium

authors： Martinsen A,Baeyens N,Yerna X,Morel N

更新日期：2012-12-01 00:00:00

abstract：:STIM and Orai isoforms orchestrate store operated Ca2+ entry (SOCE) and thus cytosolic Ca2+ fluctuations following stimulation by hormones, growth factors and further mediators. Orai1 is a target of Nedd4-2, an ubiquitin ligase preparing several plasma membrane proteins for degradation. Phosphorylation of Nedd4-2 by t...

journal_title：Cell calcium

authors： Lang F,Eylenstein A,Shumilina E

更新日期：2012-11-01 00:00:00

abstract：:Ca(2+) influx through voltage-gated Ca(2+) channels triggers the release of neurotransmitters at presynaptic terminals. Some sensory receptor cells in the peripheral auditory and visual systems have specialized synapses that express an electron-dense organelle called a synaptic ribbon. Like conventional synapses, ribb...

journal_title：Cell calcium

authors： Cho S,von Gersdorff H

更新日期：2012-09-01 00:00:00

abstract：:Here we examine the potential coupling between the synthesis of secretory proteins and the sensitivity of exocytosis to the concentration of free Ca(2+) in the cytosol ([Ca(2+)](i)) in plant cell. We therefore monitor in tobacco protoplasts the excursion of the membrane capacitance in response to an elevation of [Ca(2...

journal_title：Cell calcium

authors： Sutter JU,Denecke J,Thiel G

更新日期：2012-09-01 00:00:00

abstract：:Cooling can induce Ca(2+) signaling via activation of temperature-sensitive ion channels such as TRPM8, TRPA1 and ryanodine receptor channels. Here we have studied the mechanism of cooling-evoked Ca(2+) signaling in mouse olfactory ensheathing cells (OECs), a specialized type of glial cells in the olfactory nerve laye...

journal_title：Cell calcium

authors： Stavermann M,Buddrus K,St John JA,Ekberg JA,Nilius B,Deitmer JW,Lohr C

更新日期：2012-08-01 00:00:00

abstract：:Odontoblasts are involved in the transduction of stimuli applied to exposed dentin. Although expression of thermo/mechano/osmo-sensitive transient receptor potential (TRP) channels has been demonstrated, the properties of TRP vanilloid 1 (TRPV1)-mediated signaling remain to be clarified. We investigated physiological ...

journal_title：Cell calcium

authors： Tsumura M,Sobhan U,Muramatsu T,Sato M,Ichikawa H,Sahara Y,Tazaki M,Shibukawa Y

更新日期：2012-08-01 00:00:00

abstract：:The spatiotemporal dynamics of elementary Ca(2+) release events, such as "blips" and "puffs" shapes the hierarchal Ca(2+) signaling in many cell types. Despite being the building blocks of Ca(2+) patterning, the mechanism responsible for the observed properties of puffs, especially their termination is incompletely un...

journal_title：Cell calcium

authors： Ullah G,Parker I,Mak DO,Pearson JE

更新日期：2012-08-01 00:00:00

abstract：:The fluo family of indicators is frequently used in studying Ca(2+) physiology; however, choosing which fluo indicator to use is not obvious. Indicator properties are typically determined in well-defined aqueous solutions. Inside cells, however, the properties can change markedly. We have characterized each of three f...

journal_title：Cell calcium

authors： Hagen BM,Boyman L,Kao JP,Lederer WJ

更新日期：2012-08-01 00:00:00

abstract：:The importance of Ca2+-signaling for many subcellular processes is well established in higher eukaryotes, whereas information about protozoa is restricted. Recent genome analyses have stimulated such work also with Alveolates, such as ciliates (Paramecium, Tetrahymena) and their pathogenic close relatives, the Apicomp...

journal_title：Cell calcium

authors： Plattner H,Sehring IM,Mohamed IK,Miranda K,De Souza W,Billington R,Genazzani A,Ladenburger EM

更新日期：2012-05-01 00:00:00